Dr. DeMarco received his undergraduate degree in Chemical Engineering from Purdue University in 1978. After completing his medical degree at St. Louis University in 1982, he and his wife Bernice traveled west to the Bay Area. As his family grew to include two children, he completed his radiology residency at the Naval Hospital Oakland and his neuroradiology fellowship at UCSF in 1988. His love of MR and fascination with MR Angiography grew from those early days at UCSF. Dr. DeMarco also served his country, first as a General Medical Officer aboard the USS Kansas City and later as director of MR at the Navy's flagship west coast hospital in San Diego. He also held a joint appointment at UCSD. In San Diego, Dr. DeMarco continued his research with MR Angiography publishing the first article demonstrating excellent correlation of MRA and DSA in depicting carotid stenosis using improved post processing techniques. This work was chosen as the Best Presentation the following year at the Eastern Neuroradiological Society meeting and given as the highlight presentation during the 1994 American Society of Neuroradiology meeting. He was also chosen as Best Teacher of the Year at UCSD in 1992.
Dr. DeMarco spent the next eleven years in private practice with the University Radiology Group in New Brunswick, New Jersey. He held a joint appointment at UMDNJ where he rose to the rank of Associate Clinical Professor of Radiology. He was responsible for MR research. His work included the first clinical evaluation of multiple new MR angiographic sequences such as elliptical-centric contrast-enhanced carotid MRA, Time-Resolved Intravascular Contrast Kinetics (TRICKS), and Classic 2D Time-of-Flight. Strong collaboration with prominent investigators from the Mayo Clinic, University of Wisconsin Madison, and University of Utah made these early investigations possible. Dr. DeMarco is now extending his MRA work to include carotid plaque imaging with research collaborations at the Robarts Research Institute and University of Washington.
Dr. DeMarco has joined the faculty at Michigan State University as of January 1, 2005 as an Associate Professor of Radiology. He is planning on extending his research to include 3T contrast-enhanced carotid MRA with carotid plaque imaging, hopefully with PET correlation to evaluate for plaque activity. Correlation of the 3T carotid MRI and MRA with plaque histology and/or 3D rotational DSA is planned. Enrollment will include patients scheduled for surgical/endovascular treatment. A long-term follow up cohort of patients with mild or moderate stenosis is also planned. MSU will be the only site offering in vivo carotid plaque imaging with PET correlation and one of only a handful of universities worldwide utilizing 3T MRI to greatly improve carotid plaque imaging. Dr. DeMarco is also planning on extending time resolved MR angiography of the calf by implementation of a novel 32 element peripheral vascular coil that will allow much higher spatial and temporal resolution than is currently possible. The submillimeter resolution is important for surgical and interventional pre-operative evaluation as well as following the effectiveness of new medical therapy such as statin medication. Lastly, MSU will collaborate with MGH to bring advanced prostate MR imaging to Michigan. This will include dynamic contrast enhanced imaging with 3T that has been shown to greatly improve the sensitivity and specificity of MR to detect prostate cancer, especially in patients with rising PSA levels and negative prostate biopsy.